A year after a supermoon’s light activated a dormant gene, transforming humans into bloodthirsty werewolves and causing nearly a billion deaths, the nightmare resurfaces as the supermoon rises again. Two scientists attempt to stop the mutation but fail, leaving those exposed to the moonlight to once again become feral werewolves. Chaos engulfs the streets as the scientists struggle to reach one of their family homes, now under siege by the savage creatures.