A family is crossing the desert by car with their lizard in an aquarium. The driver is forced to an abrupt movement to avoid an accident and the aquarium falls off the car on the road. The female lizard Beans gives a ride to the lizard up to an old western town called Dirt and he goes to the bar expecting to drink water. The braggart lizard tells that he is a dangerous gunslinger called Rango and the impressed locals believe that Rango is a hero and invite him to be the sheriff. Sooner Rango finds that water is missing in town and the Major has a suspicious behavior. But when the evil Rattlesnake Jake arrives in town, Rango assumes that he is a coward and quits his position. He walks to the road but the Spirit of the West convinces him to return and fight for those that had believed in him.